Best Picture : The King's Speech - The King's Speech emerged as something of a surprise win for Best Picture. The Social Network had plenty of sway in its direction, but Colin Firth's inspired performance really took the reigns and led the film to Oscar gold. I have not seen this film, but I hear it is a solid movie.
Biggest Box Office : Toy Story 3 - Easily my favorite movie of 2010, this film is a shinning example of nostalgia done right (hear that Star Wars? Take notes!). This is a gripping movie about growing up and saying goodbye, in an almost continued theme from 2009's Up. The film handles its subject matter with strength and maturity while also hitting the laughs harder than any previous Pixar film. The scene in the incinerator is still hard to watch, and if you think that is a hard scene...try the final one. Tears. Tears for days! Hank's voice work with this film is especially great. This is among my all time favorite movies.